Respect as the Ethic of the Open Society

Karl Popper’s description of the open society in terms of respect, rather than mere tolerance, appears to be highly relevant today. Although he never explicitly addressed the issues of multiculturalism and valuepluralism in contemporary societies, Popper’s idea of respect provides an effective way to approach them. For, on the one hand, it may help to reframe current debates about multiculturalism in clearer terms. On the other, it provides a critical assessment of the widespread relativism that presents itself as a sort of panacea of all theoretical and practical problems posed by the cohabitation of groups sharing different values and worldviews. On closer scrutiny, political relativism – just as its epistemological counterpart – is not only entirely inadequate but also dangerous for the very existence of the open society. A serious look at the present situation suggests, rather, the adoption of a principle of reciprocity that is consistent with Popper’s critical pluralism and might prove to be effective in addressing the problems faced by a multicultural society

Karl Popper's Philosophical Breakthrough

Despite his well-known deductivism, in his early (unpublished) writings, Popper held an inductivist position. Up to 1929 epistemology entered Popper's reflections only as far as the problem was that of the justification of the scientific character of these fields of research. However, in that year, while surveying the history of non-Euclidean geometries, Popper explicitly discussed the cognitive status of geometry without referring to psycho-pedagogical aspects, thus turning from cognitive psychology to the logic and methodology of science. As a consequence of his reflections on the problematic relationship between geometrical-mathematical constructions and physical reality Popper was able to get over a too direct notion of such a relationship, cast doubts on inductive inference and started conceiving in a new (strictly non-inductivist) manner the relationship between theoretical and observational propositions

Hints into Kepler's method

Some of Johannes Kepler’s works seem very different in character. His youthful Mysterium cosmographicum (1596) argues for heliocentrism on the basis of metaphysical, astronomical, astrological, numerological, and architectonic principles. By contrast, Astronomia nova (1609) is far more tightly argued on the basis of only a few dynamical principles. In the eyes of many, such a contrast embodies a transition from Renaissance to early modern science. However, Kepler did not subsequently abandon the broader approach of his early works: similar metaphysical arguments reappeared in Harmonices mundi libri V (1619), and he reissued the Mysterium cosmographicum in a second edition in 1621, in which he qualified only some of his youthful arguments. I claim that the conceptual and stylistic features of the Astronomia nova – as well as of other “minor” works, such as Strena seu De nive sexangula (1611) or Nova stereometria doliorum vinariorum (1615) – are intimately related and were purposely chosen because of the response he knew to expect from the astronomical community to the revolutionary changes in astronomy he was proposing. Far from being a stream-of-consciousness or merely rhetorical kind of narrative, as many scholars have argued, Kepler’s expository method was carefully calculated both to convince his readers and to engage them in a critical discussion in the joint effort to know God’s design

A B-cell receptor-related gene signature predicts survival in mantle cell lymphoma: Results from the Fondazione Italiana Linfomi MCL-0208 trial

Mantle cell lymphoma patients have variable clinical courses, ranging from indolent cases that do not require immediate treatment to aggressive, rapidly progressing diseases. Thus, diagnostic tools capable of stratifying patients according to their risk of relapse and death are needed. This study included 83 samples from the Fondazione Italiana Linfomi MCL-0208 clinical trial. Through gene expression profiling and quantitative real-time PCR we analyzed 46 peripheral blood and 43 formalin-fixed paraffin-embedded lymph node samples. A prediction model to classify patients was developed. By analyzing the transcriptome of 27 peripheral blood samples, two subgroups characterized by a differential expression of genes from the B-cell receptor pathway (B-cell receptor low and B-cell receptor high ) were identified. The prediction model based on the quantitative real-time PCR values of six representative genes (AKT3, BCL2, BTK, CD79B, PIK3CD, and SYK), was used to classify the 83 cases (43 B-cell receptor low and 40 B-cell receptor high ). The B-cell receptor high signature associated with shorter progression-free survival (P=0.0074), selected the mantle cell lymphoma subgroup with the shortest progression-free survival and overall survival (P=0.0014 and P=0.029, respectively) in combination with high ( extgreater30%) Ki-67 staining, and was an independent predictor of short progression-free survival along with the Mantle Cell Lymphoma International Prognostic Index-combined score. Moreover, the clinical impact of the 6-gene signature related to the B-cell receptor pathway identified a mantle cell lymphoma subset with shorter progression-free survival intervals also in an external independent mantle cell lymphoma cohort homoge-nously treated with different schedules. In conclusion, this 6-gene signature associates with a poor clinical response in the context of the MCL-0208 clinical trial. (clinicaltrials.gov identifier: 02354313)

Risk factors associated with adverse fetal outcomes in pregnancies affected by Coronavirus disease 2019 (COVID-19): a secondary analysis of the WAPM study on COVID-19.

Objectives To evaluate the strength of association between maternal and pregnancy characteristics and the risk of adverse perinatal outcomes in pregnancies with laboratory confirmed COVID-19. Methods Secondary analysis of a multinational, cohort study on all consecutive pregnant women with laboratory-confirmed COVID-19 from February 1, 2020 to April 30, 2020 from 73 centers from 22 different countries. A confirmed case of COVID-19 was defined as a positive result on real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) assay of nasal and pharyngeal swab specimens. The primary outcome was a composite adverse fetal outcome, defined as the presence of either abortion (pregnancy loss before 22 weeks of gestations), stillbirth (intrauterine fetal death after 22 weeks of gestation), neonatal death (death of a live-born infant within the first 28 days of life), and perinatal death (either stillbirth or neonatal death). Logistic regression analysis was performed to evaluate parameters independently associated with the primary outcome. Logistic regression was reported as odds ratio (OR) with 95% confidence interval (CI). Results Mean gestational age at diagnosis was 30.6+/-9.5 weeks, with 8.0% of women being diagnosed in the first, 22.2% in the second and 69.8% in the third trimester of pregnancy. There were six miscarriage (2.3%), six intrauterine device (IUD) (2.3) and 5 (2.0%) neonatal deaths, with an overall rate of perinatal death of 4.2% (11/265), thus resulting into 17 cases experiencing and 226 not experiencing composite adverse fetal outcome. Neither stillbirths nor neonatal deaths had congenital anomalies found at antenatal or postnatal evaluation. Furthermore, none of the cases experiencing IUD had signs of impending demise at arterial or venous Doppler. Neonatal deaths were all considered as prematurity-related adverse events. Of the 250 live-born neonates, one (0.4%) was found positive at RT-PCR pharyngeal swabs performed after delivery. The mother was tested positive during the third trimester of pregnancy. The newborn was asymptomatic and had negative RT-PCR test after 14 days of life. At logistic regression analysis, gestational age at diagnosis (OR: 0.85, 95% CI 0.8-0.9 per week increase; pPeer reviewe

Maternal and perinatal outcomes of pregnant women with SARS-CoV-2 infection

Objectives To evaluate the maternal and perinatal outcomes of pregnancies affected by SARS-CoV-2 infection. Methods This was a multinational retrospective cohort study including women with a singleton pregnancy and laboratory-confirmed SARS-CoV-2 infection, conducted in 72 centers in 22 different countries in Europe, the USA, South America, Asia and Australia, between 1 February 2020 and 30 April 2020. Confirmed SARS-CoV-2 infection was defined as a positive result on real-time reverse-transcription polymerase chain reaction (RT-PCR) assay of nasopharyngeal swab specimens. The primary outcome was a composite measure of maternal mortality and morbidity, including admission to the intensive care unit (ICU), use of mechanical ventilation and death. Results In total, 388 women with a singleton pregnancy tested positive for SARS-CoV-2 on RT-PCR of a nasopharyngeal swab and were included in the study. Composite adverse maternal outcome was observed in 47/388 (12.1%) women; 43 (11.1%) women were admitted to the ICU, 36 (9.3%) required mechanical ventilation and three (0.8%) died. Of the 388 women included in the study, 122 (31.4%) were still pregnant at the time of data analysis. Among the other 266 women, six (19.4% of the 31 women with first-trimester infection) had miscarriage, three (1.1%) had termination of pregnancy, six (2.3%) had stillbirth and 251 (94.4%) delivered a liveborn infant. The rate of preterm birth before 37 weeks' gestation was 26.3% (70/266). Of the 251 liveborn infants, 69/251(27.5%) were admitted to the neonatal ICU, and there were five (2.0%) neonatal deaths. The overall rate of perinatal death was 4.1% (11/266). Only one (1/251, 0.4%) infant, born to a mother who tested positive during the third trimester, was found to be positive for SARS-CoV-2 on RT-PCR. Conclusions SARS-CoV-2 infection in pregnant women is associated with a 0.8% rate of maternal mortality, but an 11.1% rate of admission to the ICU. The risk of vertical transmission seems to be negligible. (C) 2020 International Society of Ultrasound in Obstetrics and Gynecology.Peer reviewe

Natura senza dogmi. Per un approccio razionale al dibattito sull'ambiente

La crescita demografica, il progresso tecnologico e la riflessione etica hanno posto da decenni il problema dell'interazione tra uomo e ambiente, che la crisi economica degli ultimi anni ha contribuito ad acuire. Lontano dai clamori della moda e dalla superficialità che troppo spesso inquinano il dibattito, gli autori dei contributi a questo volume si propongono, ognuno con prospettive e formazioni diverse, di fare dell'ambiente non un'arma di scontro fra ideologie, ma un motivo di confronto di idee critico, razionale, aperto